Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

  • STATUS
    Recruiting
  • participants needed
    200
  • sponsor
    National Taiwan University Hospital
Updated on 7 November 2020
sepsis
critical illness
antioxidants
systemic inflammatory response syndrome
organ failure
shock
acute lung injury
acute respiratory distress syndrome

Summary

In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients. The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.

Details
Condition Shock, Septicemia
Treatment Chemiluminescence Analyzer
Clinical Study IdentifierNCT00745888
SponsorNational Taiwan University Hospital
Last Modified on7 November 2020

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