Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury

    Not Recruiting
  • participants needed
  • sponsor
    University of Michigan
Updated on 21 January 2021
spinal cord disorder


This study proposes to test the efficacy of Venlafaxine HCI in reducing mild to moderate symptoms of depression among persons with Spinal Cord Injury (SCI). This study recruits either traumatic or non-traumatic injured persons with SCI living in the community.


The successes of psychological and pharmacological modes of intervention in treating depression, both alone and combined, are well documented in the literature. While a great deal of research has identified specific clinical indications for many antidepressants currently available in the general population, little is known about the clinical indications of these agents in SCI. This study is proposed to test the benefits of Venlafaxine HCI (Effexor XR) for reducing mild to moderate symptoms of depression among people with SCI. As a secondary outcome, this study will assess also the benefits of this medication in reducing severity of symptoms of pain, and enhancing subjects' perceived health and participation in the community. The intervention will last 12 weeks and there will be 13 assessments and data collection points. Data will be collected at 26 weeks also. Eight face to face contacts are anticipated.

Condition Spinal Cord Injury
Treatment Placebo, Venlafaxine HCI
Clinical Study IdentifierNCT00735670
SponsorUniversity of Michigan
Last Modified on21 January 2021

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