Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases.

  • STATUS
    Recruiting
  • participants needed
    2948
  • sponsor
    Hospital Arnau de Vilanova
Updated on 7 November 2020
atherosclerosis
diabetes
cardiovascular disease
aspirin
hypertension
atorvastatin
chronic disease
type 2 diabetes mellitus
clopidogrel
LDL Cholesterol
simvastatin
primary prevention
cholesterol level
hyperlipidemia
cholesterol measurement

Summary

The incidence of cardiovascular diseases is still high and further efforts should be done in primary prevention. The main objective is to quantify the burden of subclinical atherosclerosis using non-invasive techniques,and to study the impact of this assessment and consequent treatment in the progression of atherosclerosis and in the incidence of cardiovascular diseases.

Description

We will perform non-invasive techniques (carotid Intima-Media Thickness, CAC score and ankle-brachial index) to individuals at intermediate cardiovascular risk.With these results, we will classify participants in: no atherosclerosis, mild, moderate and severe atherosclerosis, and therapeutic targets will be set according to pre-defined algorithms. The end-point will be the course of atherosclerosis measured by cIMT/CAC score (2 years) and the incidence of CVD at 5 years of follow-up.

Details
Condition Cardiovascular Disease, Atherosclerosis
Treatment Enalapril, rimonabant, Simvastatin or Atorvastatin, Aspirin or clopidogrel
Clinical Study IdentifierNCT00734123
SponsorHospital Arnau de Vilanova
Last Modified on7 November 2020

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