China Intensive Lipid Lowering With Statins in Acute Coronary Syndrome

  • participants needed
  • sponsor
    Ministry of Science and Technology of the People´s Republic of China
Updated on 7 November 2020
cardiac event
low density lipoprotein
intravascular ultrasound
hmg-coa reductase inhibitor
LDL Cholesterol


In summary, the CHILLAS study will be the first multicenter study performed in a Chinese population using a patient-level analysis to compare the effects and safety of intensive statin therapy with that of moderate statin therapy. Therefore, it will determine whether "lower is better", that is, whether LDL cholesterol lowering to a level of approximately 100mg/dl provides a benefit inferior to that of LDL cholesterol lowering to a much lower level; examine the role of inflammatory markers in predicting cardiac events and response to statin therapy; and evaluate the effects of statin therapy on regression of coronary atherosclerosis using IVUS.


The CHILLAS study is planned to evaluate whether intensive treatment with statins for 2 years results in a reduction of cardiovascular events in patients with ACS. A total of 1,600 patients will be randomly assigned to receive intensive statin therapy (atorvastatin, 20 or 40 mg/d, or equivalent dose of other statins) or moderate therapy (atorvastatin, 10 mg/d, or equivalent dose of other statins). Both groups receive dietary counseling. Over a 2-year follow-up period, the primary outcome measure is the time to occurrence of cardiac death, nonfatal acute myocardial infarction, revascularization with either percutaneous coronary intervention or coronary-artery bypass grafting, documented unstable angina or severe heart failure requiring emergency hospitalization, and stroke. The planned duration is between December 2006 and December 2009.

Condition Acute Coronary Syndrome
Treatment Atorvastatin
Clinical Study IdentifierNCT00728013
SponsorMinistry of Science and Technology of the People´s Republic of China
Last Modified on7 November 2020


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