Immunotherapy in Peripheral T Cell Lymphoma - the Role of Alemtuzumab in Addition to Dose Dense CHOP

  • participants needed
  • sponsor
    University of Göttingen
Updated on 7 November 2020
measurable disease
b-cell lymphoma
t-cell lymphoma
peripheral t-cell lymphoma


Peripheral T cell lymphomas comprise 10-15% of all malignant lymphomas. The prognosis is significantly worse than that of aggressive B cell lymphomas. The prospects of elderly patients are especially poor, with an estimated disease free survival of only 25% after three years. Previous phase II trials have demonstrated a significant activity of the monoclonal anti CD52 antibody alemtuzumab in primary and relapsed T cell lymphoma. The investigators thus propose to investigate the value of adjuvant alemtuzumab in combination with dose dense CHOP-14 in patients with previously untreated peripheral T cell lymphoma.

Condition Angiocentric T-cell lymphoma, Angioimmunoblastic Lymphadenopathy
Treatment alemtuzumab, Chemotherapy
Clinical Study IdentifierNCT00725231
SponsorUniversity of Göttingen
Last Modified on7 November 2020


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