Pleurectomy/Decortication (Neo) Adjuvant Chemotherapy and Intensity Modulated Radiation Therapy to the Pleura in Patients With Locally Advanced Malignant Pleural Mesothelioma

  • STATUS
    Not Recruiting
  • End date
    Jul 18, 2023
  • participants needed
    81
  • sponsor
    Memorial Sloan Kettering Cancer Center
Updated on 23 May 2022
renal function
cancer
metastasis
pemetrexed
neutrophil count
carboplatin
chemotherapy regimen
immunomodulators
pleural mesothelioma
pleurectomy

Summary

For patients with this type of cancer, the standard of care is treatment with chemotherapy. Radiation therapy is typically not used. This is because radiation to the entire lining of the lung has many side effects that are often severe including damage to the lung (pneumonitis). There is a new radiation technique using Intensity Modulated Radiation Therapy (IMRT) that has been shown to reduce many of the side effects of standard radiation therapy. This type of radiation therapy specifically targets the lining of the lung, where you have your cancer, and reduces the risk of damaging the lung itself. The purpose of this study is to test the safety and implementation of standard pleurectomy/decortication (removal of the surface lining of the lung) and standard chemotherapy followed by IMRT performed at other centers. Patients will undergo pleurectomy/decortication chemotherapy and hemithoracic pleural IMRT to the pleura in patients with malignant pleural mesothelioma.

Details
Condition Mesothelioma
Treatment Intensity Modulated Radiation Therapy, Pleurectomy/Decortication, pemetrexed and cisplatin or carboplatin
Clinical Study IdentifierNCT00715611
SponsorMemorial Sloan Kettering Cancer Center
Last Modified on23 May 2022

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