Last updated on February 2011

Perioperative Lidocaine or Epidural Anesthesia on Outcomes in Complex Spine Surgery


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Wound Infection | Vomiting | Pain | Nausea
  • Age: Between 18 - 80 Years
  • Gender: Male or Female
  • Other:
    18 to 80 years old at time of surgery - adult patients differ from pediatric patients
    in that adult spines are stiffer than pediatric patient.
    Male or female patients undergoing complex spinal surgery using posterior approach
    only.
    Spine surgery only on the lumbar and thoracic regions - focused range of spinal
    column with greater anticipated blood loss as compared to cervical spine surgery
    (Fujita, 1998 - Complications of spinal fusion in adults greater than 60 years old).
    Fusion requiring screws and instrumentation - high volume blood loss anticipated with
    urgeries requiring fusion versus without fusion (Deyo,1992), and with
    instrumentation versus without instrumentation.
    Surgery performed at Cleveland Clinic with informed consent signed prior to sedation
    or anesthesia - consistent surgical team.

You may not be eligible for this study if the following are true:

  • Allergy or hypersensitivity to sufentanil, bupivacaine, morphine, or any component of
    formulations - serious adverse reaction that requires surgery be discontinued.
    Current or recent drug abuse (within past 6 months) - alters post-operative
    complications.
    Pregnancy - risks to fetus and mother potentially fatal.
    Immune system disease such as HIV, AIDS - alters measurement of inflammatory markers
    and possible post-operative complications.
    Undergoing immunosuppressive treatment - alters measurement of inflammatory markers.
    Recent history of sepsis - alters measurement of inflammatory markers.
    Contraindications to lidocaine such as heart block and hepatic insufficiency.
    Heart failure with ejection fraction less than 30%.
    Liver dysfunction manifested with increased liver enzymes to double the normal and
    INR of 2 or higher.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.