Last updated on September 2014

Dasatinib in Treating Patients With Locally Advanced or Metastatic Mucosal Melanoma Acral Melanoma or Vulvovaginal Melanoma That Cannot Be Removed By Surgery


Brief description of study

RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well dasatinib works in treating patients with locally advanced or metastatic mucosal melanoma or acral melanoma.

Detailed Study Description

OBJECTIVES: Primary - To estimate the objective tumor response rate in patients with KIT-positive, unresectable, locally advanced or metastatic acral or mucosal melanoma treated with dasatinib monotherapy. Secondary - To estimate the response duration in patients treated with this drug. - To estimate the progression-free survival of patients treated with this drug. - To evaluate the safety profile of this drug in these patients. - To evaluate the PDGFR expression and activation of Src family kinases in tumor samples and correlate these parameters with response to treatment. OUTLINE: This is a multicenter study. Patients receive oral dasatinib twice daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Tissue samples may be collected from some patients for correlative studies. After completion of study therapy, patients are followed up periodically for up to 5 years.

Clinical Study Identifier: NCT00700882

Find a site near you

Start Over

Billings Clinic - Downtown

Billings, MT United States
  Connect »

Stanford Cancer Center

Stanford, CA United States
  Connect »

CCOP - Mount Sinai Medical Center

Miami Beach, FL United States
  Connect »

Kuakini Medical Center

Honolulu, HI United States
  Connect »

Castle Medical Center

Kailua, HI United States
  Connect »

Kauai Medical Clinic

Lihue, HI United States
  Connect »

Elmhurst Memorial Hospital

Elmhurst, IL United States
  Connect »

McFarland Clinic, PC

Ames, IA United States
  Connect »

Costas L. Constantinou, MD

Bettendorf, IA United States
  Connect »

Lawrence Memorial Hospital

Lawrence, KS United States
  Connect »

Menorah Medical Center

Overland Park, KS United States
  Connect »

Saint Luke's Hospital - South

Overland Park, KS United States
  Connect »

CCOP - Kansas City

Prairie Village, KS United States
  Connect »

CCOP - Wichita

Wichita, KS United States
  Connect »

Dickinson County Healthcare System

Iron Mountain, MI United States
  Connect »

Borgess Medical Center

Kalamazoo, MI United States
  Connect »

Bronson Methodist Hospital

Kalamazoo, MI United States
  Connect »

West Michigan Cancer Center

Kalamazoo, MI United States
  Connect »

Fairview Ridges Hospital

Burnsville, MN United States
  Connect »

Hutchinson Area Health Care

Hutchinson, MN United States
  Connect »

Minnesota Oncology - Maplewood

Maplewood, MN United States
  Connect »

New Ulm Medical Center

New Ulm, MN United States
  Connect »

CCOP - Metro-Minnesota

Saint Louis Park, MN United States
  Connect »

Park Nicollet Cancer Center

Saint Louis Park, MN United States
  Connect »

United Hospital

Saint Paul, MN United States
  Connect »

Lakeview Hospital

Stillwater, MN United States
  Connect »

Ridgeview Medical Center

Waconia, MN United States
  Connect »

North Kansas City Hospital

Kansas City, MO United States
  Connect »

Research Medical Center

Kansas City, MO United States
  Connect »

Saint Luke's East - Lee's Summit

Lee's Summit, MO United States
  Connect »

Parvin Radiation Oncology

Liberty, MO United States
  Connect »

Heartland Regional Medical Center

Saint Joseph, MO United States
  Connect »

St. John's Regional Health Center

Springfield, MO United States
  Connect »

St. Peter's Hospital

Helena, MT United States
  Connect »

Glacier Oncology, PLLC

Kalispell, MT United States
  Connect »

Mid Dakota Clinic, PC

Bismarck, ND United States
  Connect »

Barberton Citizens Hospital

Barberton, OH United States
  Connect »

Bryn Mawr Hospital

Bryn Mawr, PA United States
  Connect »

Lewistown Hospital

Lewistown, PA United States
  Connect »

UPMC Cancer Centers

Pittsburgh, PA United States
  Connect »

Mount Nittany Medical Center

State College, PA United States
  Connect »

CCOP - Main Line Health

Wynnewood, PA United States
  Connect »

Marshfield Clinic - Chippewa Center

Chippewa Falls, WI United States
  Connect »

UW Cancer Center Johnson Creek

Johnson Creek, WI United States
  Connect »

D.N. Greenwald Center

Mukwonago, WI United States
  Connect »

St. Nicholas Hospital

Sheboygan, WI United States
  Connect »

Rocky Mountain Oncology

Casper, WY United States
  Connect »

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.