Last updated on March 2010

Docetaxel Plus Oxaliplatin as Therapy in Patients With Pancreatic Cancer

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Pancreas Neoplasms
  • Age: Between 18 - 100 Years
  • Gender: Male or Female
  • Other:
    Dated and signed informed concent
    Histologically or cytologically proven metastatic or locally advanced adenocarcinoma
    of the exocrine pancreas (stadium UICC III/IV)
    Presence of at least one measurable (according to RECIST criteria) marker lesion
    (primary tumor or metastasis) outside of an area that was previously subjected to
    radiation therapy
    Failure of a palliative first line therapy of a metastatic or locally advanced
    adenocarcinoma of the exocrine pancreas due to: Progress within 3 months after a
    first-line therapy Discontinuation of a first-line therapy due to toxicity
    Age >= 18 years
    Karnofsky index > 60%
    Expected live span > 12 weeks
    Sufficient bone marrow reserve: Granulocytes >= 1.5 x 109/L and Platelets >= 100 x
    109/L and Hemoglobin >= 9 g/L
    Serum Bilirubin < 2 x upper normal limit or 2.5 x upper normal limit in case of
    hepatic metastasis (biliary drainage allowed)
    AST/ALT < 2.5 x upper normal limit

You may not be eligible for this study if the following are true:

  • Every other cancer or secondary cancer besides the basal cell carcinoma of the skin
    or the carcinoma in situ of the cervix uteri. Inclusion of patients with other types
    of cancer that were successfully treated and that did not relapse within the last 5
    years is possible
    Pregnancy or lactation
    Patients able to reproduce that do not adhere to strict contraception
    Presence of brain metastasis
    Severe, uncontrolled infection
    Preexisting peripheral neuropathy > grade I
    Preexisting severe illnesses such as unstable coronary artery disease or uncontrolled
    cardiac arrhythmia
    Justified disbelief in the compliance of the patient
    Parallel participation in another clinical trial

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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