Allogeneic Transplantation for Pediatric Leukemias With Unrelated Donors

  • participants needed
  • sponsor
    Ann & Robert H Lurie Children's Hospital of Chicago
Updated on 7 November 2020
total body irradiation
ejection fraction
antithymocyte globulin


The study proposes the use of Fludarabine, Busulfan, Anti Thymocyte Globulin Rabbit (ATG) and Total Body Irradiation as a preparative regimen before hematopoietic stem cell transplant from unrelated donor peripheral blood stem cells (PBSC). The hypothesis states that the 100 day mortality after this type of transplant will be significantly below the accepted standards, which is about 30% for unrelated donors.


The primary objective of this study is to evaluate the toxicity (as measured as 100 day survival) after hematopoietic stem cell transplant from an unrelated donor with a novel preparative regimen of Fludarabine, Busulfan, Anti-Thymocyte Globulin, and Total Body Irradiation for pediatric patients with leukemia. The secondary objectives are to evaluate the relapse-free and overall survival after hematopoietic stem cell transplant as well as to evaluate the incidence of acute and chronic graft-versus-host disease after this preparative regimen.

Condition leukemia
Treatment busulfan, Fludarabine, Total body irradiation, Thymoglobulin
Clinical Study IdentifierNCT00679536
SponsorAnn & Robert H Lurie Children's Hospital of Chicago
Last Modified on7 November 2020


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