Last updated on May 2008

Erlotinib Versus Carboplatin/Vinorelbine in Elderly Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Non-Small Cell Lung Cancer
  • Age: Between 70 - 100 Years
  • Gender: Male or Female
  • Other:
    Histologically or cytological proven NSCLC, stage lll b (with pleural effusion) or
    tage lV.
    Tumour is locally advanced and not suitable for surgery and radiotherapy is not
    Neither cytostatic nor immunological pre-treatment
    Age >70 years
    At least one measurable lesion (RECIST criteria) that was not previously irradiated
    ECOG Performance Status 0-1
    Life expectancy > 3 month
    Adequate bone marrow function: ANC > 1.5 x 109/L, Platelets > 100 x 109/L
    Adequate liver function: Total Bilirubin < 1.5 x ULN, GOT/GPT< 3 x ULN (existent
    liver metastases < 5 x ULN)
    Adequate renal function:creatinine clearance > 45 ml/min (calculated according to
    Fertile men must agree to use an effective method of birth control while
    participating in this study
    Signed written informed consent

You may not be eligible for this study if the following are true:

  • Uncontrolled metastasis in the CNS
    Acute, heavy uncontrolled infection
    Any other serious concomitant disease or medical condition, which could interfere
    with participating in this study
    Severe hypersensitivity to Erlotinib or any other component
    Hypersensitivity to Carboplatin and/or other platinum compounds
    Hypersensitivity to Vinorelbin or other Vinca-alkaloids
    Patients with a history of other active malignancy in the past 5 years (with the
    exception of carcinoma in situ of the cervix, non melanomatous skin cancers or local
    prostate carcinoma that was surgically treated successfully) are excluded.
    Participation in another clinical trial with any investigational drug at the same
    time or within 30 days prior to registration
    Psychological, familial, social or geographical situations limiting the compliance
    with the study requirements

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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