Magnetic Resonance (MR) Spectroscopy In Familial Mediterranean Fever (FMF) Patients

  • STATUS
    Recruiting
  • participants needed
    20
  • sponsor
    Sheba Medical Center
Updated on 22 January 2022

Summary

Familial Mediterranean fever (FMF) is an inherited disorder of unknown etiology, characterized by recurrent episodes of fever, peritonitis and/or pleuritis. Fever is the cardinal manifestation of FMF and is present in most attacks accompanied by abdominal pain. Another clinical manifestation in patients with FMF is exertional muscle pain, usually in the thigh, which appears even after minor exercise or physical activity in young patients with generally good health (other than FMF) and in good physical condition. Some patients also complain of ankle edema after relatively minor physical activity, which subsides after a night rest. Although these manifestations are quite common in FMF patients and form part of the minor criteria for the diagnosis, the etiopathogenesis has not been examined. The purpose of the suggested study is to evaluate and characterize the anatomical and biochemical changes in the muscles of the thigh and in the ankle triggered by physical activity in FMF patients complaining of exertional lower leg myalgias and edema after minor physical exercise.

Details
Condition Familial Mediterranean Fever
Clinical Study IdentifierNCT00658060
SponsorSheba Medical Center
Last Modified on22 January 2022

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