Trial of Preoperative Hepatic and Regional Arterial Chemotherapy (PHRAC) to Prevent Postoperative Liver Metastasis of Colorectal Cancer

  • STATUS
    Recruiting
  • participants needed
    600
  • sponsor
    Fudan University
Updated on 7 November 2020
Investigator
jianmin xu, professor
Primary Contact
Zhongshan Hospital, Fudan University (2.3 mi away) Contact
metastasis
oxaliplatin
liver metastasis
floxuridine
adenocarcinoma
adenocarcinoma of colon

Summary

The purpose of this study is to investigate whether preoperative hepatic and regional arterial chemotherapy are able to prevent liver metastasis and improve overall survival in patients receiving curative colorectal cancer resection.

Description

We administered FUDR, MMC and Oxaliplatin as preoperative hepatic and regional arterial chemotherapy (PHRAC) to patients with Stage II or Stage III colorectal cancer without apparent liver metastasis based on a thorough preoperative evaluation. The study endpoints were disease-free survival, overall survival, and liver metastasis-free survival as evaluated by intent-to-treat analysis.

Details
Condition Colorectal Cancer
Treatment Surgery, Preoperative hepatic and regional arterial chemotherapy using oxaliplatin, MMC and FUDR
Clinical Study IdentifierNCT00643877
SponsorFudan University
Last Modified on7 November 2020

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