Study of Apatinib as an Inhibitor of Tumor Angiogenesis

  • STATUS
    Recruiting
  • participants needed
    18
  • sponsor
    Fudan University
Updated on 7 November 2020
growth factor
neutrophil count
mitomycin
solid tumor

Summary

Apatinib is a tyrosin-inhibitor agent targeting at vascular endothelial growth factor receptor (VEGFR), so it can inhibit tumor angiogenesis. This phase I study aims to determine the drug's toxicity and to find a dose level to be used in a phase II study in solid tumor patients.

Description

Apatinib is a tyrosin-inhibitor agent targeting at VEGFR (vasoendothelial growth factor receptor) to inhibit tumor angiogenesis. The anti-angiogenesis effect of apatinib has been viewed in preclinical tests (see protocol). This phase I clinical study is going to evaluate its toxicity and to find an appropriate dose level to be used in a phase II study in heavily treated solid tumor patients.

Details
Condition Cancer
Treatment apatinib
Clinical Study IdentifierNCT00633490
SponsorFudan University
Last Modified on7 November 2020

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