Last updated on February 2008

Using Furosemide to Prevent Fluid Overload During Red Blood Cell Transfusion in Neonates


Brief description of study

The purpose of this study is to investigate the effects of intravenous furosemide on cardio-respiratory performance in neonates receiving a packed red blood cell (PRBC) transfusion who are considered at high risk of volume overload.

Detailed Study Description

Red cell transfusion is a very common practice in neonates, particularly in preterm infants. It has been estimated that approximately 300,000 neonates undergo transfusions annually. The decision to administer a blood transfusion to a sick anemic neonate is made after consideration of multiple clinical factors, including: poor weight gain, oxygenation failure, and recurrent apnea and bradycardia. These decisions are also influenced by physician preferences. For many years, furosemide has been used routinely by physicians during and after blood transfusions in neonates and other age groups. The rationale behind this common practice is to reduce the vascular overload that may be imposed by the additional blood volume delivered during transfusion. This belief, however, lacks the support of scientific clinical evaluation.

Clinical Study Identifier: NCT00618852

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Edmond Kelley, MD

Mount Sinai Hospital
Toronto, ON Canada
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Patrick McNamara, MD

The Hospital for Sick Children
Toronto, ON Canada
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Recruitment Status: Open


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