Use of Polysomnography for Non-Invasive Ventilation Settings' Optimization

  • STATUS
    Recruiting
  • participants needed
    45
  • sponsor
    Tyco Healthcare Group
Updated on 7 November 2020

Summary

The aim of this randomized controlled trial is comparing the improvement of diurnal PaCO2 in OHS patients after one month of NIV treatment depending upon the tools used for adjusting settings. In one arm settings will be adjusted using only nocturnal oxygen SaO2 and PaCO2 at awakening whereas in the other arm patients will benefit from a complete polysomnography under NIV.

Description

Initiation of NIV treatment implies technical adjustments (choice of mask and ventilator), but also patient education by the nurses and medical staff. The settings are generally adjusted during the daytime in awake patients. The appropriateness of these settings is generally not optimal during sleep as many respiratory events (hypopnoea, apnea, leaks, desynchronization, and glottic closure) may occur under NIV then reducing the effectiveness of treatment. These nocturnal abnormalities are routinely evaluated by measuring their consequences, i.e. oxygen desaturation and the level of PaCO2 after wake up. Some teams are now proposing to better characterize what happens when using NIV during sleep using polysomnography (PSG). The precise characterization of residual events under treatment may allow optimizing ventilator settings.

Details
Condition Pickwickian Syndrome
Treatment GoodKnight 425ST - Mallinckrodt DF, Tyco Healthcare
Clinical Study IdentifierNCT00603096
SponsorTyco Healthcare Group
Last Modified on7 November 2020

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