Last updated on July 2011

Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Intermittent Claudication | Peripheral Vascular Diseases
  • Age: Between 16 - 100 Years
  • Gender: Male or Female
  • Other:
    persistent (>3 months) disabling claudication (Fontaine's stages IIb or Rutherford's
    categories 3, viz. pain free walking distance less than 100 meter) despite optimal
    therapy or critical limb ischemia (Fontaine's stages III/IV or Rutherford's
    categories 4-6)
    ineligibility for angioplasty or bypass procedures
    male of female, >18 years old
    life expectancy > 1 year
    written informed consent

You may not be eligible for this study if the following are true:

  • candidates for angioplasty or bypass procedures
    inability to undergo bone marrow harvesting
    any condition in the affected limb that is anticipated to require surgical
    intervention in the first weeks after BM-MNC treatment
    life threatening co-morbidity
    poorly controlled diabetes (HbA1C > 10%)
    active malignancy in the 5 years prior to treatment
    INR >1.5 at the time of bone-marrow harvest
    bleeding diathesis
    inability to undergo arterial catheterization
    inability to follow the protocol and to comply with the follow up requirements
    any other conditions that, in the opinion of the investigators, could interfere with
    the therapy or could pose a significant threat to the subject if the investigational
    therapy was to be initiated

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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