Last updated on January 2008

Usefulness of Anticoagulant Treatment in First Isolated Symptomatic Calf Vein Thrombosis


Brief description of study

The CACTUS study is a 6-week evaluation of anticoagulant treatment effect on reducing infrapopliteal deep vein thrombosis (DVT) extension to proximal veins. Its aim is to demonstrate if the low molecular weight heparin (LMWH) use is really necessary for the treatment of a first infrapopliteal DVT episode, knowing the potential risks that their use induce.

Detailed Study Description

This study will compare the evolution of the infrapopliteal DVT into two groups of patients, one treated with LMWH (Nadroparine) + elastic compression during 6 weeks and the second one treated with a placebo + elastic compression during 6 weeks. Patients will be assigned to intervention groups by chance, and neither physician, nor patient, will know which product is administrated (study in "double blind"). Each patient will benefit of an acute survey by repeated Echo-Doppler exams.

Clinical Study Identifier: NCT00539058

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Recruitment Status: Open


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