Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer

  • STATUS
    Recruiting
  • participants needed
    200
  • sponsor
    Samsung Medical Center
Updated on 22 January 2022
cancer

Summary

Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.

Description

Patients with newly diagnoised colorectal cancer will be eligible. They will undergo detailed history taking including family history, and molecular stuidies including microsatellite instability test and immunohistochemistry for DNA mismatch repair protein with pre-selection. Any abnormal finding in molecular stuides will be offered genetic testing (after testing methylation status for patients with abnormalities in MLH1).

Details
Condition Colonic Neoplasms
Clinical Study IdentifierNCT00516230
SponsorSamsung Medical Center
Last Modified on22 January 2022

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