Effects of Celecoxib On Restenosis After Coronary Intervention and Evolution of Atherosclerosis Trial

  • STATUS
    Recruiting
  • participants needed
    900
  • sponsor
    Seoul National University Hospital
Updated on 7 November 2020
atherosclerosis
infarction
celecoxib
myocardial infarction
angina pectoris
infarct
stress test

Summary

To evaluate the effect of celecoxib use for 3 month after drug-eluting stent implantation - on restenosis - on clinical outcome such as target lesion revascularization, thrombotic event, myocardial infarction, death - on inflammatory biomarkers

Description

Restenosis is the major adverse effect of coronary stent implantation. Drug-eluting stent has markedly reduced restenosis as compared with bare-metal stent, but restenosis is still the main cause of repeat coronary intervention after drug-eluting stent implantation. After coronary stent implantation, inflammatory reaction occurs in vessel wall and vascular smooth muscle cells proliferate. Celecoxib is well known to have anti-proliferative effect as well as anti-inflammatory effect, and safety of this drug is well-established. Celecoxib use for 6 month after paclitaxel-eluting stent implantation significantly reduced neointimal growth and repeat intervention without increase in adverse effect. Because inflammatory reaction seems to occur in very early period after vessel injury, reduced use of celecoxib may also be effective.

Details
Condition Coronary Restenosis, Percutaneous Transluminal Coronary Angioplasty
Treatment Celecoxib
Clinical Study IdentifierNCT00500279
SponsorSeoul National University Hospital
Last Modified on7 November 2020

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