Prophylactic Irradiation to the Contralateral Breast for BRCA Mutation Carriers Undergoing Treatment for Breast Cancer

  • STATUS
    Recruiting
  • participants needed
    240
  • sponsor
    Assaf-Harofeh Medical Center
Updated on 7 November 2020
endocrine therapy
hormone therapy
adjuvant therapy
mastectomy
lumpectomy
adjuvant chemotherapy
immunostimulant

Summary

Women with BRCA germline mutations face a very high risk of developing breast cancer during their lives. It was shown that for carrier patients, breast conservation, comprising of lumpectomy followed by whole breast radiation, was not associated with increased risk of ipsilateral breast cancer recurrence as compared with non carriers (10-15% over 10 years), especially if they also underwent prophylactic oophorectomy. Yet their risk of subsequent contralateral breast cancer was significantly increased, reported as high as 25-30% over 10 years and 40% over 15 years, as compared to 3% and 7% respectively in non carriers. The reduction in ipsilateral disease was attributed to radiation of the affected breast. We propose that for breast cancer patients with BRCA germline mutation that choose to have breast-conserving therapy and refuse prophylactic contralateral mastectomy, prophylactic radiation to the contralateral breast may reduce the rate of subsequent contralateral breast cancer and offer an option for risk reduction.

Description

Trial design and statistics:

This is a multi center- phase II open comparative trial. "Patients" - Those who choose prophylactic contralateral breast irradiation. "Controls" - Those that do not opt for prophylactic irradiation or mastectomy. Objective - to compare the rate of contralateral breast cancer in "patients" versus "controls".

Assuming that 2/3 of the eligible carrier breast cancer patients refuse the procedure: To detect a difference of 10% vs. 25% in the incidence of contralateral breast cancer with power

  • 80%, alpha = 0.05, 80 patients and 160 controls need to be enrolled.
    Treatment

Chemotherapy, Hormonal therapy and XRT to the affected breast as per treating institution.

Radiation therapy:

Patients will undergo a pre-treatment planning CT with 5mm cuts in the treatment position, on a breast board, with both arms extended above their head. The organs at risk (heart, lungs) will be contoured on the CT scan.

The affected breast (with the index lesion) and associated lymphatic drainage will be treated according to the treating physician decision. The contralateral breast will be treated with 2 tangent fields, using 1.8-2 Gy/fx to a total dose of 50-50.4 Gy. The whole breast will be treated according to traditional guidelines and as described in the RTOG/NSABP B39 study. The heart should be completely blocked for left sided breasts, included lung tissue should be reduced to minimum. No overlapping field is allowed on the skin between the two breast fields in the midline. Maximal dose should not exceed 110%.

Follow up:

The treating physician will follow the patient every 2 weeks during the radiation treatment. Side effects will be scored and recorded in the patients chart according to the Common Terminology Criteria for Adverse Events v3.0.

Subsequent follow-up schedule according to the treating institution and ASCO guidelines. Patients will undergo annual mammogram and breasts US. Annual breasts MRI and bilateral salpingo-oophorectomy will be recommended.

Ipsilateral and contralateral breast cancer will be recorded and reported. Any subsequent malignancy other than breast cancer will be reported. Long-term radiation side effects will be recorded.

Details
Condition Breast Cancer
Treatment Prophylactic radiation to the contralateral breast
Clinical Study IdentifierNCT00496288
SponsorAssaf-Harofeh Medical Center
Last Modified on7 November 2020

Eligibility

Yes No Not Sure

Inclusion Criteria

Female patient diagnosed with stage I-III breast cancer (AJCC 6), undergoing breast irradiation as part of her adjuvant therapy
The patient must be a carrier of a deleterious mutation in BRCA 1/2
Age above 30 years
The patient may receive any regimen of adjuvant chemotherapy, according to the treating physician. All cycles of chemotherapy must be completed at least 3 weeks prior to the start of radiation therapy
The patient may be treated with hormonal therapy before, during or after study entry, according to the guidelines of her treating center
The patient must have negative gadolinium based MRI of the contralateral breast, no more than 6 months prior to study entry
The patient refused prophylactic contralateral mastectomy
The patient is aware that subsequent breast cancer in the irradiated breast will probably mandate mastectomy
The patient consent for contralateral prophylactic irradiation. -

Exclusion Criteria

Metastatic breast cancer
Previous irradiation of the breast or chest wall
Pregnancy
No concurrent chemotherapy is allowed
Patients with active connective tissue diseases are excluded due to the potential risk of significant radiotherapy toxicity
Patients who are unable to lie on their back and raise their arms above their heads in the treatment planning position for radiotherapy are excluded -
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