Exercise and Respiratory Therapy in Patients With Rheumatoid Arthritis / Collagenosis and Pulmonary Hypertension

  • End date
    Dec 22, 2023
  • participants needed
  • sponsor
    Heidelberg University
Updated on 4 October 2022
rheumatic diseases
mixed connective tissue disease
right heart catheterization
systemic sclerosis
crest syndrome
pulmonary hypertension
respiratory therapy


In Patients with rheumatic disease exercise training is a well established element of therapy. In contrast patients with severe pulmonary hypertension are advised to avoid physical exertion and must not perform exercise training. This study aims to evaluate the effectivity and safety of a low-dose training program in patients with pulmonary hypertension and rheumatic disease.

Condition Pulmonary Hypertension, Connective Tissue Disease
Treatment exercise training
Clinical Study IdentifierNCT00491309
SponsorHeidelberg University
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Informed consent
Men and women 18 - 80 years
Diagnosed rheumatic disease: rheumatoid arthritis, Collagenosis (Systemic Lupus Erythematodes, Systemic Sclerosis, Sjögren-Syndrome, Sharp-Syndrome, Crest-Syndrome, Mixed connective tissue disease)
Symptomatic PAH (WHO- functional class II-IV) invasively diagnosed by right heart catheterisation
Mean pulmonary artery pressure (mPAP) > 25 mmHg
Pulmonary capillary wedge pressure (PCWP) > 15 mmHg
Pulmonary vascular resistance (PVR) at baseline >320 dyn.sec/cm5 patients under optimized medical treatment since at least 2 ½ months

Exclusion Criteria

Other forms of PAH
Pregnancy or lactation
Change in medication during the last 2 ½ months
Patients with signs of right heart decompensation
Severe impairment of walking
Unclear diagnosis
No invasive diagnosis of PH
Acute illness, infection, fever
Severe lung disease with FEV1 <50% and TLC< 70% below reference
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