Hemodynamic Response After Six Months of Sildenafil

  • STATUS
    Recruiting
  • participants needed
    27
  • sponsor
    University of Chile
Updated on 7 November 2020
hypertension
sildenafil

Summary

The purpose of this study is to determine the clinical, functional and hemodynamic response after six months of sildenafil 50 mg TID in patients with pulmonary arterial hypertension.

Description

Pulmonary arterial hypertension is a chronic devastating disease. There are few approval oral treatments. Sildenafil, a phosphodiesterase 5 inhibitors, has been recently approved for patients on functional class II and III showing hemodynamic benefits after 12 weeks of treatment. Long term hemodynamic evaluation after sildenafil treatment has not been evaluating in pulmonary arterial patients on functional class II to IV. The protocol has been designed to evaluate patients on functional class II to IV from baseline conditions and after 6 months of sildenafil treatment (50 mg po TID). Clinical (functional class), functional (walked distance-6 minute walking test) and Hemodynamic evaluation is planned to be performed at baseline and after 6 months of treatment.

Details
Treatment oral sildenafil
Clinical Study IdentifierNCT00483626
SponsorUniversity of Chile
Last Modified on7 November 2020

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