Last updated on April 2007

A Validation/Interventional Study on Stress Index in Predicting Mechanical Stress in ARDS Patients


Brief description of study

30% of ARDS patients ventilated according to NIH protocol presents CT scan evidence of hyperinflation. Functional analysis of pressure-time curve (Stress Index=SI) has been shown to identify this condition in experimental settings. We tested the hypothesis that the SI is an accurate predictor of mechanical stress due to overdistention in ARDS patients.

Detailed Study Description

The study presents two parts : a preliminary validation study and a clinical study.

Clinical Study Identifier: NCT00465374

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V. M. Ranieri, MD

University of Turin, Department of Anesthesia and Intensive Care Medicine
Turin, Italy
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