Dietary Intervention in Follicular Lymphoma

  • STATUS
    Recruiting
  • participants needed
    45
  • sponsor
    Oslo University Hospital
Updated on 22 January 2022
rituximab

Summary

A dietary intervention study in patients with Follicular Lymphoma (FL) Stage III/IV to assess the ability of several dietary factors to induce apoptosis, inhibit cell proliferation and modulate tumor cell infiltrate in vivo.

Description

Dietary factors plays an important role in the prevention of several diseases. The cardiovascular disease mortality have dropped dramatically the last 20 years, but the relative death rates from cancer remains fairly stable. There is reason to believe that factors in the tumors microenvironment is of great importance for the outcome of many malignant diseases, including FL. Factors predicting a poor outcome are associated with inflammation, oxidative stress which both impair the hosts immune response and produces growth stimulatory signals. In this open study with 45 patients to be included we seek to perform a dietary intervention with comparison of apoptosis rate, proliferation rate and immune cell infiltrate before and after the intervention period.

Details
Condition Follicular Lymphoma
Treatment Omega 3 fatty acids (EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid)), Selenium (L-Selenomethionine),, Garlic extract (Allicin), Pomegranate juice (ellagic acid), Grape juice (resveratrol, quercetin), Green Tea (Epigallocathechin gallate)
Clinical Study IdentifierNCT00455416
SponsorOslo University Hospital
Last Modified on22 January 2022

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