Aspirin and Enalapril in Microalbuminuric Type 2 Diabetes Mellitus Patients

  • STATUS
    Recruiting
  • participants needed
    20
  • sponsor
    Hospital de Clinicas de Porto Alegre
Updated on 7 November 2020
diabetes mellitus
type 2 diabetes mellitus

Summary

Research design: randomized, double-blind, placebo-controlled crossover study to evaluate the putative interference of low-dose aspirin (for 8 weeks) on enalapril antiproteinuric properties in microalbuminuric type 2 diabetes mellitus patients

Description

Research design: randomized, double-blind, placebo-controlled crossover study Patients: Microalbuminuric (urinary albumin excretion [UAE]30-300 mg/d)type 2 diabetes mellitus patients without ischemic heart disease or peptic ulcer Aim:To evaluate the putative interference of low-dose aspirin (300 mg/d)for 8 weeks)on enalapril antiproteinuric properties in microalbuminuric type 2 diabetes mellitus patients Study protocol:Crossover randomization to 8 weeks of enalapril 10 mg/d plus aspirin (300 mg/d) or plus placebo, and a 6-week washout period. Measurement of UAE (immunoturbidimetry) and glomerular filtration rate (51Cr-EDTA), blood pressure and metabolic control at baseline and at the end of each period. Statistical analyses: Bland&Altman analyses for crossover trials.

Details
Condition Diabetes Mellitus
Treatment Aspirin
Clinical Study IdentifierNCT00427271
SponsorHospital de Clinicas de Porto Alegre
Last Modified on7 November 2020

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