Last updated on March 2010

Second-line Treatment in Patients With Small Cell Lung Cancer (SCLC)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Small Cell Lung Cancer
  • Age: Between 18 - 100 Years
  • Gender: Male or Female
  • Other:
    Small-cell lung cancer.
    Patients who, after (at least) a first line of chemotherapy based on platinum, had a
    partial response and then progressed, or who had a complete response and then
    relapsed within three months following the last course of this first-line therapy.
    Measurable or assessable disease.
    Life expectancy >2 months.
    Patients with a therapeutic risk level of <5 points (see section 6: "Treatment
    Age >18 years;
    Performance status (WHO) <2;
    One measurable target lesion in a non irradiated region;
    Prior radiotherapy authorized unless it targeted the only measurable lesion;
    Biological criteria: WBC >2000/mm3, PMN >1500/mm3, platelets >100 000/mm3,
    creatinemia <2 x ULN, bilirubinemia metastases)
    normal ECG
    written informed consent.

You may not be eligible for this study if the following are true:

  • Non small-cell lung cancer.
    No objective response to platinum-based therapy
    Complete response lasting more than three months after the last course of first-line
    Symptomatic brain metastases.
    Bone metastases, carcinomatous lymphangitis, ascites or pleurisy as sole assessable
    disease manifestations.- Concurrent participation in another clinical trial.
    Therapeutic risk level of 6 points or more (see table)
    Uncontrolled clotting disorders;
    Uncontrolled severe infection;
    History of another malignancy, except for cervical carcinoma in situ or basocellular
    cancer that are considered cured;
    Psychological, familial, sociological or geographic circumstances preventing
    treatment follow-up as defined in the protocol;
    Patients deprived of their rights for administrative or legal reasons.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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