Last updated on August 2013

Observation Combination Chemotherapy Radiation Therapy and/or Autologous Stem Cell Transplant in Treating Young Patients With Neuroblastoma


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Neuroblastoma
  • Age: - 21 Years
  • Gender: Male or Female
  • Other:
    DISEASE CHARACTERISTICS:
    Diagnosis of neuroblastoma by histology using tumor tissue or as evidenced by the
    presence of distinct neuroblastoma cells in the bone marrow AND elevated
    catecholamine metabolites (i.e., homovanillic acid [HVA] and vanillylmandelic acid
    [VMA]) in blood or urine
    Newly diagnosed disease (for patients in the low-risk group)
    Diagnosis from tumor tissue (for patients in the medium-risk group)
    Meets criteria for 1 of the following risk groups:
    Low-risk group
    No MYCN amplification AND meets 1 of the following criteria:
    Stage 1 disease
    Stage 2 disease with no chromosome 1p deletion or imbalance
    Stage 3 disease with no chromosome 1p deletion or imbalance (for
    patients < 2 years of age)
    Stage 4S disease (for patients < 1 year of age)
    Medium-risk group
    No MYCN amplification AND meets 1 of the following criteria:
    Stage 2 disease with chromosome 1p deletion or imbalance
    Stage 3 disease with chromosome 1p deletion or imbalance
    Any chromosome 1p status (for patients ≥ 2 years of age)
    Stage 4 disease (for patients < 1 year of age)
    High-risk group, meeting 1 of the following criteria:
    Any stage disease with MYCN amplification
    Any MYCN status (for patients ≥ 1 year of age)
    PATIENT CHARACTERISTICS:
    Not pregnant or nursing
    Negative pregnancy test
    Fertile patients must use effective contraception
    PRIOR CONCURRENT THERAPY:
    No prior nephrectomy or other mutilating surgery as initial surgery (for patients in
    the low-risk group)
    No other concurrent anticancer therapy

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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