Safety and Efficacy Study of Ex Vivo Immunotherapy for Treatment of Aplastic Anemia

  • participants needed
  • sponsor
    Shenzhen Zhongxing Yangfan Biotech Co. Ltd.
Updated on 7 November 2020
bone marrow transplant
immunosuppressive agents
aplastic anemia


Our hypothesis is that ex vivo activated immune cells would produce multiple known and unknown potent hematopoietic cytokines, working in concert, these cytokines help stem cell growth and differentiation. Additionally, these cells travel and home to bone marrow as well as spleen and liver involved in hematopoietic activities, where direct cell-cell contact may be beneficial.


Patients will be required to stay in our hospitals to receive the immunotherapy. Allogeneic peripheral blood mononuclear cells from healthy donors and the autologous peripheral mononuclear cells will alternately used for the treatment. Patients are expected to spend at least 6 to 12 months in the hospital and won't be released until they have improved significantly.

Condition Aplastic Anemia
Treatment Ex Vivo Immunotherapy
Clinical Study IdentifierNCT00399971
SponsorShenzhen Zhongxing Yangfan Biotech Co. Ltd.
Last Modified on7 November 2020


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