Last updated on May 2008

Memantine for Agitation in Dementia

Brief description of study

We plan to evaluate the use of memantine in Alzheimer's disease to control agitation in the acute situation i.e under 12 weeks

Detailed Study Description

Agitation is a cause of morbidity and mortality in Alzheimer's due to distress and use of medication with side effects. Memantine has beed shown to be associated with less agitation and a recent study by forrest pharmaceuticals failed to recruit. We will perform a 12 week rct in 164 patients to test this hypothesis in a locality with no competing studies and in a clinical setting where the drug is not often used. We will compare with placebo and also use a rescue protocol derived from international best practice.

Clinical Study Identifier: NCT00371059

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Oxleas Nhs Foundation Trust
Dartford, United Kingdom
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Kent and Medway NHS and Social Care Partnership Trust
Folkestone, United Kingdom
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Recruitment Status: Open

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