T Cell Repertoire Analysis of Immune Mediated Skin Diseases

  • STATUS
    Recruiting
  • End date
    Oct 24, 2021
  • participants needed
    50
  • sponsor
    University of California, Davis
Updated on 10 March 2021
skin disorder
psoriasis
skin disease
mycosis

Summary

This study is designed to identify the cells of the immune system that cause skin disease such as psoriasis and mycosis fungoides. Blood samples from many patients will be compared in hopes of finding common cells and molecules responsible for skin diseases. Results of this study will increase our knowledge about immune mediated skin disease.

Description

The aim of the study is to characterized the T cell repertoire of individuals with immune mediated skin disease (e.g. psoriasis and mycosis fungoides). Peripheral blood with be collected from volunteers with psoriasis, mycosis fungoides and age matched controls. Fifteen tablespoons of blood will be collected prior to the initiation of treatment and again after the patient shows a clinical response to treatment. The time between blood draws will be no less than 3 months. There will be no more than two blood draws per patient. Blood samples will be used to determine the patient's HLA haplotype via PCR and DNA sequencing. After the patient's haplotype has been established the activated T cell repertoire will be analyzed for clonal expansions. Clonal expansions in the T cell repertoire will be determined by immunoscope analysis, which is a PCR based technique.

Details
Condition Psoriasis, Mycosis Fungoides, cutaneous T-cell lymphoma, Psoriasis and Psoriatic Disorders
Clinical Study IdentifierNCT00368784
SponsorUniversity of California, Davis
Last Modified on10 March 2021

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