Study of Optimal Treatment Plan in Hypertensives With Anti-AT1-Receptor Autoantibody

  • STATUS
    Recruiting
  • participants needed
    600
  • sponsor
    Huazhong University of Science and Technology
Updated on 7 November 2020
ace inhibitor
ATR
candesartan

Summary

The autoantibodies against AT1 receptor (ATR-AA), behaving like an agonist were detected in patients with hypertension. ATR-AA which can blocked by ARB may play a role in the pathogenesis of hypertension. The present study is to explore whether AT1 receptor blocker has superior anti-hypertensive effect in patients with positive ATR-AA hypertension. Patients with 2 grade hypertension were recruited and ATR-AA was assayed by ELISA. A study was carried out and the efficacy of anti-hypertension was compared between candesartan cilexetil and ACE inhibitor imidapril.

Details
Condition Hypertension
Treatment candesartan cilexetil
Clinical Study IdentifierNCT00360763
SponsorHuazhong University of Science and Technology
Last Modified on7 November 2020

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