Performance of Executive functions and relation to verb processing and decision making in Alzheimer Disease

  • STATUS
    Recruiting
  • days left to enroll
    3
  • participants needed
    15
  • sponsor
    Hofstra University
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Updated on 20 July 2023
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Accepts healthy volunteers

Summary

The purpose of this study is to assess the relationship between cognitive skills (i.e., executive functions), and make comparisons to verb processing and decision making for individuals with Alzheimer Disease as compared to healthy adults.

Description

This project will assess the relationship between executive functioning and linguistic processing of verbs in adults with Alzheimer Disease (AD) and make comparisons with a group of healthy adults. A demographic questionnaire, a cognitive screening (MOCA; Nasreddine, 1996), and a hearing screening will be administered prior to the assessment. The NIH Toolbox Cognition Battery in Adults (NIHTB-CB; Carlozzi et al., 2014) will be implemented to assess overall executive functioning skills. In addition, a passive eye-tracking experiment will be conducted to examine the visual attention of verbs. The results of the eye-tracking experiment will be compared to determine the relationship between verb processing and executive functioning on patients with AD and healthy elderly adults. More research is needed to explore verbs from a linguistic processing point-of-view and these findings can lead to more information on lexical organization of verbs and the role that they play in sentences (Kim & Thompson, 2004). Furthermore, this project will examine how healthy and AD individuals approach different decision-making tasks. There is evidence that cognitive and emotional deficits affect inhibition and impulsive decisions (see Rochat et al., 2008). Here, we will measure impulsivity with both self-report scales (e.g., UPPS) and objective tasks and examine how these scores affect classic decision-making outcomes that pit rewards against time. Specifically, both healthy individuals and individuals with AD will complete a go/no go computer task and a Stroop task (a measure of inhibition). Next, they will complete the following decision-making tasks:

Details
Condition Alzheimer's Disease
Clinical Study IdentifierTX312843
SponsorHofstra University
Last Modified on20 July 2023

Eligibility

 Yes No Not Sure

Inclusion Criteria

Diagnosis of early-stage Alzheimer disease
Can have aided hearing and vision

Exclusion Criteria

Not a diagnosis of early-stage Alzheimer disease
Any other neurological and/or psychiatric disorders
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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