The Application of Serum DNA Methylation for Patients With HCC

  • End date
    Mar 31, 2026
  • participants needed
  • sponsor
    Chiayi Christian Hospital
Updated on 6 April 2023


The goal of this single-arm prospective study is to evaluate the application of serum DNA methylation for HCC patients with normal alpha-fetoprotein. The main question it aims to answer is

. Is the dynamic change of serum DNA methylation correlated to recurrence or treatment response of HCC


The enrolled individuals with HCC and normal serum alpha-fetoprotein level would receive serum DNA methylation test before their treatment (including all kinds of recommened HCC treatment). Then regularly serum DNA methylation test would be done at 4th~8th weeks, 16th week, 32th week and 48th week. If the enrolled patients did not have HCC recurrence during at 48th week. The regular check of serum DNA methylation would be canceled. The enrolled patients would be observed till 96th week. If there is any recurrence during 48~96th week, one time of serum DNA methylation would be checked at the time of recurrence. The observation and intervention would be completed at 96th week.

Condition Hepatocellular Carcinoma
Treatment Serum DNA methylation
Clinical Study IdentifierNCT05764551
SponsorChiayi Christian Hospital
Last Modified on6 April 2023


Yes No Not Sure

Inclusion Criteria

Age ≥ 20 years old
The diagnosis of hepatocellular carcinoma (HCC) according to AASLD 2018 clinical guidelines or histology report
Individuals with HCC and normal serum alpha-fetorpotein level (<20 ng/ml)
Individuals who could sign informed consent

Exclusion Criteria

The histology report revealed non-HCC, HCC mixed with cholangiocarcinoma or sarcomatoid HCC
Individuals with HCC and other concurrent malignancies
Individuals with chronic kidney disease who could not tolerate contrast-enhanced dynamic images
Individuals ever receiving any organ transplantation
Individuals with HIV infection
Individuals who could not able to understand and sign informed consent
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