Diagnostic Value of Calponin 2 in Identifying Tubal Pregnancies (CNN2)

  • End date
    Jan 31, 2025
  • participants needed
  • sponsor
    Mỹ Đức Hospital
Updated on 4 April 2023


Ectopic pregnancy (EP) is the implantation of a fertilized egg outside the main cavity of the uterus. EP is one of the most common gynecologic surgical emergencies , and one of leading causes of maternal mortality in the first trimester of pregnancy. Embryo implantation exerts different pressure on uterine and tubal epithelial and smooth muscle cells, calponin 2 (CNN2) expression at the implantation site would differ between intrauterine pregnancy and tubal pregnancy. The investigators conduct this study to find out the diagnostic value of CNN2 in identifying tubal pregnancies.


This is a case-control prospective study. Women age 18-35 years old, come to My Duc, My Duc phu Nhuan Hospital and Ngoc Lan Clinic and have the indication of testing beta human chorionic gonadotropin (hCG) for determining pregnancy status because of 1-14 days period delay with or without abdominal pain, vaginal bleeding or after assisted reproductive technology. Those women will be introduced about the study. If they agree to take part in and write the consent form, they will be taken 5ml of blood more at the same time of testing beta hCG. Blood sample will then be centrifuged and collected serum will then be stored at -80 celsius degree.

Women with negative beta hCG will be excluded. Women with positive beta hCG will be followed-up pregnancy as routine until 12 6/7 weeks of gestational age (GA). At this time, those women will be screened using including and excluding criteria for each group. They then be put group into (1) tubal pregnancy, (2) viable pregnancy and (3) early pregnancy loss.

Stored serum sample will be defrosted and measured CNN2 concentration.

Condition Tubal Pregnancy
Treatment calponin 2
Clinical Study IdentifierNCT05591599
SponsorMỹ Đức Hospital
Last Modified on4 April 2023


Yes No Not Sure

Inclusion Criteria

Patients aged 18 years old to < 35 years old
Transvaginal ultrasound records images of a living fetus in the uterine with
embryos and fetal heart activity until 12 6/7 weeks of gestation (ultrasound or
last menstrual period)

Exclusion Criteria

BMI > 30 kg/m2
A co-existing ectopic pregnancy
Multiple pregnancies
Refuse to participate in the study
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