Late Onset Alzheimer's Disease (LOAD)

  • STATUS
    Recruiting
  • End date
    Sep 14, 2026
  • participants needed
    10000
  • sponsor
    Columbia University
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Updated on 15 February 2023
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dementia
alzheimer's disease
dementia, frontotemporal
Accepts healthy volunteers

Summary

The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.

Description

The purpose of this study is to focus on the genetic influences on Alzheimer's disease (AD) risk. Specifically, the investigators hypothesize that one or more genes, other than the previously identified susceptibility gene apolipoprotein-E (APOE), or the 3 genes associated with early-onset familial AD, presenilin-1 (PS-1), presenilin-2 (PS-2) or B-amyloid precursor protein (APP), increase the risk of AD in families with multiple individuals affected with AD. The investigators propose to test this hypothesis by performing genetic linkage analysis in order to detect the chromosomal location of genes that may increase the risk of Alzheimer's disease. In addition, the investigators will study genes known to increase the risk of Alzheimer's disease and other related disorders such as early onset AD, Pick disease, corticobasal degeneration, progressive supranuclear palsy, and familial frontotemporal dementia with parkinsonism and Lewy Body Dementia.

Details
Condition Alzheimer's Disease
Treatment Blood draw, Late Onset Alzheimer's Disease (LOAD) Neuropsychological Battery Test
Clinical Study IdentifierNCT05010603
SponsorColumbia University
Last Modified on15 February 2023

Eligibility

 Yes No Not Sure

Inclusion Criteria

Established diagnosis of definite or probable AD or have a diagnosis of a related neurodegenerative disorder such as Frontotemporal Dementia (FTD) or Lewy Body Dementia (LBD) (will also recruit sporadic FTD and LBD) cases
a living sibling with probable or possible AD
a third living relative affected with AD (onset age 50 or older) or unaffected (60 or older)
participants in the proband's generation with an identified companion serving as an informant
participants who have capacity to consent or participants lacking capacity to consent with a surrogate/proxy in place to provide consent

Exclusion Criteria

failure to identify an appropriate informant
uncertainty of the clinical diagnosis of Alzheimer's disease or other related disorder
discovery of additional diagnosis that could account for the clinical manifestations
unwillingness to participate
failure to identify a living sibling with AD or other related disorder (except in the cases of sporadic FTD and sporadic LBD)
participants lacking the capacity to consent who do not have a surrogate or proxy or next of kin to provide consent
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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