Peripheral Tissue Biomarker for Diagnosis of Lewy Body Dementia and Alzheimer's Disease

    Not Recruiting
  • sponsor
Updated on 21 September 2023
cognitive impairment
alzheimer's disease
parkinson's disease
mild cognitive impairment
progressive supranuclear palsy
neurodegenerative diseases
corticobasal degeneration
Accepts healthy volunteers


The purpose of this study is to identify changes on a skin punch biopsy or olfactory mucosa (tissue in the back of the nose) sampling, in which small pieces of skin are removed or a swab or brush is placed in the back of the nose, and then tissue is sent to the laboratory for examination. The objective is to tell whether someone has Alzheimer's disease or dementia with Lewy bodies, by testing in the skin or in the back of the nose for proteins that may be found in the brain of people with these neurological conditions.


The purpose of this research is identify changes on skin biopsy, which are small pieces of skin removed and sent to the laboratory for examination, olfactory mucosa sampling, which is a sample taken with a swab or a brush from the back of the nose, and colon biopsy, a sample of large intestine that can be taken during someone’s routine colonoscopy procedure. We believe that these changes may be a way to diagnose these neurological conditions. This research study involves a visit to the Neurological Institute at University Hospitals for examination, questions, a memory test, and a blood test. People who volunteer for an optional Covid19 sub-study will return for a 6-month and 1-year study visit for Covid19 testing, bloodwork, questions, and examination. A volunteer can choose to have skin punch biopsy and/or olfactory mucosa swabbing. Someone can volunteer for one or both of these tests. A skin punch biopsy is done at the Skin Study Center at University Hospitals Cleveland Medical Center and/or a olfactory mucosa swabbing is done by an otolaryngologist (ear nose and throat doctor) at University Hospitals. Someone who is already planning to have a colonoscopy or sigmoidoscopy may choose to volunteer for a colon biopsy for study purposes.

Condition Alzheimer's Disease, Parkinson's disease, Dementia with Lewy bodies, Progressive supranuclear palsy, Corticobasal degeneration
Clinical Study IdentifierTX310329
SponsorNIH (NINDS)
Last Modified on21 September 2023

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