Primary: To test the hypothesis that
apixaban is superior to aspirin for the prevention of recurrent stroke in
patients with cryptogenic ischemic stroke and atrial cardiopathy.
Secondary: To test the hypothesis that the relative
efficacy of apixaban over aspirin increases with the severity of atrial
ARCADIA is a multicenter, biomarker-driven, randomized, double-blind,
active-control, phase 3 clinical trial of apixaban versus aspirin in patients
who have evidence of atrial cardiopathy and a recent stroke of unknown cause.
Eleven hundred subjects will be recruited over 2.5 years at up to 200 sites in
and out of the NINDS StrokeNet consortium. Subjects will be followed for a
minimum of 1.5 years and a maximum of 7 years for the primary efficacy outcome
of recurrent stroke and the primary safety outcomes of symptomatic intracranial
hemorrhage and major hemorrhage other than intracranial hemorrhage.
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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