Athlete Brain Health and Aging Study

  • End date
    May 31, 2023
  • sponsor
    HHS/National Institutes of Health
Updated on 19 January 2023
Nino Nadareishvili
Primary Contact
Online Study Center (online study) Contact
Online studies
Accepts healthy volunteers


The Athlete Brain Health and Aging Study is currently conducting research on former D1 collegiate athletes and former NFL players above the age of 30. Participation in the study will assist with our understanding of the impact of concussion, sub-concussive head injury, and sport participation on men’s health and well-being. The study will take 60-90 minutes through video conferencing and has an optional visit to Duke University for in-person testing. Individuals will be compensated up to $175 for their participation in the study.


This project explores innovative approaches to address functional, cognitive, and psychosocial vulnerabilities in concussed men, and may ultimately reduce the risk of Chronic Traumatic Encephalopathy (CTE), and Alzheimer’s disease resulting from concussions. A cohort of former collegiate football players and a cohort of retired NFL athletes will be prospectively studied and compared against socio-demographically matched control groups of men from the general population on a wide array of functional and psychosocial measures. The research activities include a health questionnaire and cognitive assessment & test battery completed over Zoom with a member of the research team. As a multi-site study with Duke University, participants who can go to Duke University will complete the cognitive assessment there, as well as provide blood and urine samples and complete an MRI. The in-person visit takes four to five hours on a single day and travel compensation is provided.

Condition Mild Cognitive Impairment, Alzheimer's Disease, Male, Age 30+, Former NFL Player, Former D1 Football Player, Former D1 Athlete, Speaks English, US Resident
Clinical Study IdentifierTX310265
SponsorHHS/National Institutes of Health
Last Modified on19 January 2023


Yes No Not Sure

Inclusion Criteria

Adult males age 30 and older
Former NFL and Division I football players
Former Division 1 Non-Contact Athlete (Baseball, Cross Country, Fencing, Golf, Gymnastics, Rifle, Rowing, Skiing, Swimming and Diving, Tennis, Track and Field, Volleyball)
Fluent in English
Resident of USA

Exclusion Criteria

Under the age of 30
Diagnosis of dementia (In-Person Only)
History of a learning disability or developmental delay (In-Person Only)
Implanted metal devices/if ever worked with metal (In-Person Only)
Claustrophobia (In-Person Only)
History of neurological injury or disease (severe head trauma, seizures, strokes, prior neurosurgery, or currently under the care of a neurologist or neurosurgeon)
Lesions on conventional MRI (In-Person Only)
Substance abuse dependence (except for nicotine and cannabis)
Axis I psychiatric disorders (except PTSD, Generalized Anxiety Disorder, Panic Disorder, Agoraphobia, Other specific phobias, Anxiety not otherwise specified, and Depression)
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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