Clinical Study to Evaluate the Possible Efficacy and Safety of L- Carnitine and Sildenafil in Children Having Beta Thalassemia With Increased Tricuspid Regurgitant Jet Velocity

  • STATUS
    Recruiting
  • End date
    Jul 8, 2024
  • participants needed
    44
  • sponsor
    Tanta University
Updated on 28 October 2022

Summary

This study aims to investigate the possible efficacy and safety of L_Carnitine and Sildenafil on patient with Beta thalassemia complicated with increased Tricuspid Regurgitant Jet Velocity

Details
Condition Beta Thalassemia With Increased Tricuspid Regurgitant Jet Velocity
Treatment Sildenafil, L_carnitine
Clinical Study IdentifierNCT05584956
SponsorTanta University
Last Modified on28 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Children with Beta thalassemia major who have increased TRJV more than 2.5m/s
Children age from 6-18 years

Exclusion Criteria

Others hemolytic anemia
Young age before 6 years of age
Allergy to Sildenafil or L-carnitine
Patient with documented causes of pulmonary hypertension rather than caused by Beta thalassemia
Hepatic dysfunction: serum Alanine Aminotransferase (ALT) 3X
Renal dysfunction: Creatinine level greater than or equal to 1.2 mg/dl
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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