Cladribine Combined With G-CSF and Cytarabine as a Salvage Treatment in Refractory/Relapsed Acute Lymphoblastic Leukemia

  • End date
    Dec 31, 2024
  • participants needed
  • sponsor
    The First Affiliated Hospital of Soochow University
Updated on 27 October 2022


To explore the efficiency and safety of CLAG regimen in R/R ALL


R/R Acute Lymphoblastic Leukemia has poor response to second-line chemotherapy.Here,we want to explore efficiency and safety of CLAG regimen in R/R ALL.

Condition Acute Lymphoblastic Leukemia
Treatment Fludarabine, cladribine
Clinical Study IdentifierNCT05578378
SponsorThe First Affiliated Hospital of Soochow University
Last Modified on27 October 2022


Yes No Not Sure

Inclusion Criteria

The patients meet the diagnostic criteria for Relapsed/Refractroy B-ALL. ECOG score is 0-3
Expecting life span is more than 6 weeks

Exclusion Criteria

Patients are combined with severe organ dysfunction or organ failure: Cardiac failure
Liver and kidney insufficiency
Patients are combined with severe infection or other complications that can not tolerate
Patients are considered as other tumor progression. Patients have used cladribine. Pregnant
and lactating women will not be included
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