PSMA-PET Imaging of Salivary Gland Tumours and Other Rare Cancers

  • STATUS
    Recruiting
  • End date
    Jun 27, 2024
  • participants needed
    24
  • sponsor
    National Cancer Centre, Singapore
Updated on 27 October 2022

Summary

The objectives of this pilot feasibility study, which is on the use of 68-Ga PSMA PET imaging of salivary gland tumours, are

  • to determine the proportion of patients with high PSMA-ligand uptake on Ga-68 PSMA imaging in locally advanced, recurrent or metastatic salivary gland cancers and other rare cancer; and
  • to determine if in vitro PSMA expression correlates to PSMA-ligand uptake on Ga-68 PSMA imaging in locally advanced, recurrent or metastatic salivary gland cancers and other rare cancers.

The hypotheses of this study are that there is high PSMA-ligand uptake on Ga-68 PSMA imaging in locally advanced, recurrent or metastatic salivary gland cancers and other rare cancers; and that in vitro PSMA expression correlates to PSMA-ligand uptake on Ga-68 PSMA imaging.

Description

The potential participant will be screened and confirmed for eligibility by the appropriate study-team member. A signed IRB approved informed consent will be obtained prior to conducting any study-related procedures.

On the scheduled visit date for the study,

  • An intravenous cannula (plug) will be inserted in a vein in the participant's arm, through which the 68-Ga PSMA radiotracer for the scan will be injected. The infusion will take about 1-2 minutes.
  • PET imaging will be performed with a dedicated PET/CT scanner. 2.5-6.0 mCi (depending on weight of the patient) of PSMA radiotracer will be injected intravenously.
  • A PET scan will be done around 60 minutes after the injection of the 68-Ga PSMA imaging agent.
  • During imaging, the participant will be asked to lie still and may be asked to hold his/her breath for a few seconds.
  • Imaging will be performed using a PET/CT, which will take 30 to 40 minutes to complete. Imaging of the body from vertex to mid thigh or feet will be obtained.
  • After the completion of the scan, the plug will be removed.

A Final Study Visit will take place on that one scheduled day. The participant will not need to visit the doctor's office during the course of the study outside of their usual scheduled doctor's follow up appointments.

Details
Condition Salivary Gland Tumor, Rare Malignant Neoplasm
Treatment 68-Ga PSMA PET scan
Clinical Study IdentifierNCT05581979
SponsorNational Cancer Centre, Singapore
Last Modified on27 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Diagnosis of haematological malignancies
Patients with more than one cancer diagnosis
Contraindication to 68Ga-PSMA PET/CT
E.g.: pregnant patients, breast feeding patients, renal impairment, liver impairment, allergy to components of the test
Any psychological, familial, sociological or geographical condition potentially
hampering compliance with the study protocol and follow up schedule
Ongoing participation in any other clinical trial
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  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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