Change in Skin Surface Temperature at the Knee Area on Both Sides When Using Mild Moxibustion Manipulation at Mingmen Acupoint With Moxa Stick: A Pilot Study

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    Bui Pham Minh Man
Updated on 23 October 2022
Accepts healthy volunteers


Moxibustion plays an important role in Traditional Medicine treatments, which treats and prevents diseases by burning a herb preparation containing Moxa (Artemisia vulgaris, Mugwort) to stimulate the meridians of human body. Moxibustion is considered a safe and effective traditional therapy. Mild moxibustion is a kind of therapeutic method which characterized by wide indications, simple manipulation and comfortable feeling, is commonly used in clinical treatment. Mingmen acupoint located on the midline of the lower back, in the depression below the spinous process of the 2nd lumbar vertebra (L2). Its indications include Yang-deficiency syndrome, Cold-Stagnation syndrome, Cold Excessive syndrome,... and it is closely related to the knee area through the path of Thoroughfare Vessel (one of the Eight Extraordinary Vessels). In our study, we investigate the change in skin surface temperature at the knee area on both sides when using mild moxibustion manipulation at Mingmen acupoint with moxa stick in healthy volunteers.


Participants and Methods: A randomized controlled trial is conducted by comparing the change in skin surface temperature before and after using mild moxibustion manipulation at the research acupoint (Mingmen (GV-4) acupoint) or the control acupoint (the left side Pishu (BL-20) acupoint) in healthy volunteers. A total of 38 participants will undergo 2 trial phases, corresponding to 2 times of moxibustion in 8 days, each time is 7 days apart. In the first trial phase: participants received moxibustion at left side Pishu (BL-20) acupoint. In the second trial phase: participants received moxibustion at Mingmen (GV-4) acupoint. The primary outcome was the change in skin surface temperature at the local stimulated area and the knee area on both sides when using mild moxibustion manipulation at Mingmen acupoint. This trial will be performed as a pilot study.

Condition Healthy Volunteers
Treatment Mild moxibustion with moxa stick
Clinical Study IdentifierNCT05578027
SponsorBui Pham Minh Man
Last Modified on23 October 2022


Yes No Not Sure

Inclusion Criteria

Healthy males and females were individual age between enough 18 and 30 years old
BMI: 18.5 - 23 kg/m2
Mental alertness, good contact, cooperation with researchers
Had no psychiatric stress problem during moxibustion day (confirmed by answering the DASS 21 questionaire with stress point less than 15 points)
Had no history of cardio-vascular disease, diabetes, hyperthyroidism, hypothyroidism
Vital sign within normal limits
Heart rates from from 60 to 99 beats/minute
Systolic blood pressure between 90 and 139 mmHg
Diastolic blood pressure between 60 and 89 mmHg
Breathing rate: 16 ± 3 times/minute
Body temperature: 36.59 ± 0.43 ℃
SpO2 from 95 to 100%
Volunteers who agree to participate and sign the Informed Consent Form, following a
detailed explanation of clinical trials
Not currently participating in other intervention studies

Exclusion Criteria

Having an inflammatory injury in the site of the skin to be investigated
Medical history of asthma or allergy with moxa smoke
Using heat therapy, for example massage, cupping therapy, acupuncture in the site of the skin to be investigated within 24 hours
Applying chemical or pharmaceutical products to the site of the skin to be survey before conducting the study
Other diseases that could affect or interfere with outcomes, including common cold or flu
Playing sport 2 hours before the study
Taking stimulants such as beer, alcohol, coffee and tobacco within 24 hours before conducting the study
Skin surface temperature disorders or sensation disorders at lower-back or knee area
Staying up at night or having insomnia before moxibustion day
Women during menstruation period, pregnancy, or breastfeeding
Currently using certain drugs which dilate blood vessels and drop in blood pressure
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