Therapeutic Endovascular Embolization for Intracranial Meningioma (e-men)

  • STATUS
    Recruiting
  • End date
    Aug 22, 2037
  • participants needed
    30
  • sponsor
    St. Olavs Hospital
Updated on 22 October 2022
anesthesia
karnofsky performance status
intracranial meningioma

Summary

The natural course for meningioma suggests that a majority will grow over time. Treatment is usually indicated in growing or symptomatic meningiomas. Surgery is usually primary treatment, but there is a significant risk of adverse effects. Stereotactic radiotherapy is most often reserved to treat relapses after surgery, and except for surgery and radiotherapy there are no other established treatment methods. Endovascular embolization may be used in selected cases as a preoperative adjunct to reduce intraoperative bleeding. There is a need for more treatment options in patients with meningioma, both in uncomplicated, asymptomatic cases and in more complex cases. The aim of this study is to assess radiological and clinical results of therapeutic endovascular embolization for meningioma

Details
Condition Meningioma
Treatment Endovascular embolization
Clinical Study IdentifierNCT05416567
SponsorSt. Olavs Hospital
Last Modified on22 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Radiological diagnose of typical intracranial meningioma (homogenous contrast enhancement or dural attachment)
Indication for treatment due to growth, symptoms or both
Tumor location suggestive of vascular supply via middle meningeal artery branches
Age 18 years or older
Karnofsky performance status of 90 or better (able to carry on normal activity and work)

Exclusion Criteria

Informed consent not possible (e.g. language barriers, aphasia, cognitive impaired)
Previously treated for meningioma
Intraosseous growth
Tumor related brain edema
Neurofibromatosis type 2
Systemic cancer
Epilepsy
Progressive neurodegenerative disorder (eg. MS, Parkinsons disease)
History of psychiatric disorder
Unfit for participation for any other reason judged by the physician including patients
Contraindications to MRI
Allergic to contrast agents
Relative contraindications to endovascular treatment judged from CT angiography (tortoise carotid arteries, carotid stenosis, calcified aortic arch, anatomical vascular variants/anomalies suggesting increased risk with endovascular treatment)
DSA (Digital subtraction angiography) from carotid artery suggesting that significant vascular supply is from other vessels than the MMA
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