Metabolic Risk Factors and Myocardial Oxygenation Reserve (META-MORE) ((META-MORE))

  • End date
    Dec 20, 2023
  • participants needed
  • sponsor
    McGill University Health Centre/Research Institute of the McGill University Health Centre
Updated on 20 October 2022
systolic blood pressure
cholesterol level
hdl cholesterol
central obesity
serum hdl cholesterol
Accepts healthy volunteers


The purpose of this study is to use MRI images using the OS-CMR technique to view the differences in the hearts of healthy volunteers and participants with a condition called Metabolic Syndrome. Our objectives for this project are to compare these two groups and to view how health risks, blood test results, and the time since a Metabolic diagnosis can affect heart health.


Myocardial oxygenation changes during vasoactive breathing maneuvers, observed with oxygenation-sensitive cardiac MRI, will be identified and compared between individuals considered healthy and those fitting the criteria of the Metabolic Syndrome.

Condition Metabolic Syndrome
Treatment Cardiac MRI
Clinical Study IdentifierNCT05574153
SponsorMcGill University Health Centre/Research Institute of the McGill University Health Centre
Last Modified on20 October 2022


Yes No Not Sure

Inclusion Criteria

Patient Participants
Age 18-80
Informed Consent
Diagnosis of MetS (through at least 3 MetS characteristics (abdominal obesity, high triglyceride level, low HDL cholesterol, high systolic blood pressure, and high fasting glucose levels)
Healthy Volunteers
Age 18-80
No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system
No Smoking

Exclusion Criteria

General MRI contraindications
Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy
Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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