Intraoperative Retrolaminar Block as Opioid Free Anesthesia and Enhanced Recovery After Posterior Lumber Spine Discectomy: A Randomized Controlled Study

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  • participants needed
  • sponsor
    Zagazig University
Updated on 19 October 2022
Accepts healthy volunteers


Opioid-free intraoperative protocols have been successfully used in specific surgical populations with equal or superior results to classic general anesthetic approaches. In instances where opioid-free anesthesia may not be entirely feasible, there exists a continually growing body of evidence that the modern anesthesiologist has a potent pharmacologic and regional anesthetic arsenal that can reduce the amount of opioids required to effectively treat pain.

Retrolaminar block is considered a new, easy and simple technique with decreasing incidence of complications such as hypotension, pleural and nerve injury. Its efficacy had been investigated in trauma patients


  • Null hypothesis: Intraoperative retrolaminar block will not produce opioid sparing anesthetic effect and enhanced recovery after posterior lumber spine discectomy.
    • Alternative hypothesis: Intraoperative retrolaminar block will produce opioid sparing anesthetic effect and enhanced recovery after posterior lumber spine discectomy.

Condition Opioid Free Anesthesia
Treatment Standard analgesia (paracetamol +fentanyl), Retrolaminar block with bupivacaine + magnesium sulfate + dexamethasone
Clinical Study IdentifierNCT05312866
SponsorZagazig University
Last Modified on19 October 2022


Yes No Not Sure

Inclusion Criteria

Written informed consent from the patient
Age: 21-60 years old
Sex: both sex (males and females)
American Society of Anesthesiologist Physical status: ASA 1& II
Body Mass Index (BMI) = (25-30 kg/m2)
Type of operation: elective posterior Lumbar discectomy from L3 to L5 disc space

Exclusion Criteria

Altered mental state
Patients with known history of allergy to study drugs
Advanced hepatic, renal, cardiovascular, and respiratory diseases
Patients with chronic pain
Patients receiving anticoagulants
Contraindications of regional anesthesia, e.g., allergy to local anesthetics, coagulopathy, or septic focus at site of injection
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