IrRigation of the INfected Pleural Space With antiSEptic Solution (RINSE) - a Proof of Concept Study (RINSE)
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- STATUS
- Recruiting
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- End date
- May 1, 2024
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- participants needed
- 44
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- sponsor
- Alexandria University
Summary
Pleural antiseptic irrigation (PAI) is used in conjunction with open drainage for treating adults with chronic post-thoracotomy empyema. The antiseptic povidone-iodine can safely be instilled into the pleural cavity for the purpose of pleurodesis and has recently been described for pleural irrigation in the acute management of paediatric pleural infection with good outcomes. A recent case report demonstrated the safe use of povidone-iodine pleural irrigation in a patient with complex pleural empyema with successful medical management. In a previous pilot study, antiseptic irrigation led to less referral to surgery and shorter length of hospital stay in comparison to no irrigation.
This study aims to investigate the effect of antiseptic pleural irrigation (using povidone iodine) on the inflammatory response in adults patients with pleural infection in comparison to irrigation with normal saline alone. A reduction in the systemic inflammatory response can be inferred to correlate with reduction in the infection burden in the pleural space.
Details
| Condition | Empyema, Pleural |
|---|---|
| Treatment | Normal saline, Povidone-iodine solution |
| Clinical Study Identifier | NCT05546762 |
| Sponsor | Alexandria University |
| Last Modified on | 19 October 2022 |
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