CArvedilol SR in Patients With REduced Strain and Preserved Ejection Fraction Heart Failure (CARE-preserved HF): A Prospective Randomized, Double-Blinded, Multicenter Study
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- STATUS
- Recruiting
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- End date
- Aug 30, 2024
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- participants needed
- 100
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- sponsor
- Seoul National University Bundang Hospital
Summary
Beta-blockers improve clinical outcomes in heart failure and reduced ejection fraction (HFrEF); but not in those with preserved EF. Global longitudinal strain (GLS) is a prognostic factor independent of left ventricular ejection fraction (LVEF). In a retrospective with 1969 patients with HF and LVEF of ≥40%, beta-blocker was associated with improved survival in those with low GLS (GLS <14%), but not in those with GLS ≥14%. In this prospective, randomized clinical study, the investigators will assess the effect of carvedilol in patients with HF and EF > 40% and GLS < 14% and N-terminal pro-B-type natriuretic peptide (NT-proBNP) > 400 pg/mL. The primary endpoint is the time-averaged proportional changes in NT-proBNP level from baseline through month 3. The secondary endpoints include the change in NT -proBNP at month 3 and month 6.
Details
| Condition | Heart Failure With Preserved Ejection Fraction, Beta Blocker, Myocardial Strain |
|---|---|
| Treatment | Placebo, Carvedilol |
| Clinical Study Identifier | NCT05553314 |
| Sponsor | Seoul National University Bundang Hospital |
| Last Modified on | 18 October 2022 |
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