A Real-world Comparison of FNB and FNA in ICH-required Lesions: A Prospective, Multicenter Study.

  • STATUS
    Recruiting
  • participants needed
    240
  • sponsor
    Huazhong University of Science and Technology
Updated on 2 February 2023

Summary

Endoscopic ultrasound (EUS)-guided fine needles with side fenestrations are used to collect aspirates for cytology analysis and biopsy samples for histologic analysis. The investigators conducted a large, multicenter study to compare the accuracy of diagnosis via specimens collected with fine-needle biopsy (FNB) versus fine-needle aspiration (FNA) for patients with lesions requiring immunohistochemistry (IHC) pathological diagnosis.

Description

Current guidelines recommend FNA and FNB needles equally for pancreatic and other deep-seated lesions. However, some studies indicate that the sample adequacy for histologic evaluation is higher when using FNB compared with FNA needles. The diagnosis of neuroendocrine tumor (NET), autoimmune pancreatitis (AIP), and other gastrointestinal stromal tumors require high-quality tissue sampling for IHC diagnosis. Whether FNB is superior to FNA in these IHC-required lesions remains unclear.

The investigatorsperformed this at 2 tertiary care centers in China. The study prospectively collected patients undergoing EUS for a solid mass (>1 cm) in the pancreas, abdomen, mediastinum, or pelvic cavity from December 2014 diagnosed with AIP, NET, or GIST. Patients were assigned to FNB or FNA groups according to doctors' and patients' willingness in a real-world setting. All procedures were performed by experienced endosonographers; cytologists and pathologists were blinded to the sample collection method. Patients were followed for at least 48 weeks, and final diagnoses were obtained after surgery, imaging analysis, or resolution of the lesion. The primary aim was to compare diagnostic yields of EUS-FNA with EUS-FNB for all solid masses, then separately as AIP, NET, and GIST masses. The secondary endpoint was the quality of the histologic specimen.

Details
Condition Neuroendocrine Tumors, Autoimmune Pancreatitis, Gastrointestinal Stromal Tumors
Treatment FNB group, FNA group
Clinical Study IdentifierNCT05565066
SponsorHuazhong University of Science and Technology
Last Modified on2 February 2023

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