A Randomized Controlled Trial on Reducing Oestrogen Dosage to Improve the Clinical Outcome of Frozen-thawed Embryo Transfer

  • End date
    Jun 1, 2026
  • participants needed
  • sponsor
    Nanjing University
Updated on 14 October 2022
Accepts healthy volunteers


This study is a single-center, randomized, controlled prospective study. Those who will recieve hormone replacement therapy-frozen thawed embryo transfer (HRT-FET) are enrolled in the study. To determine the effect of oestrogen dosage reducion on maternal and fetal complications in HRT-FET cycles while maintaining the similar clinical pregnancy outcome in HRT-FET cycles with regular oestrogen dosage.


According to the enrollment and exclusion criteria, the patients were enrolled, and the subjects were randomly divided into two groups by computer randomization. Group A was the reduced oestrogen dosage group (test group). Group B was the regular hormone replacement group (control group).

Condition FET
Treatment Low oestrogen dosage
Clinical Study IdentifierNCT05545592
SponsorNanjing University
Last Modified on14 October 2022


Yes No Not Sure

Inclusion Criteria

Aged between 20 and 40 years old
Frozen thawed embryo transfer is proposed, and the type of transferred embryo is blastocyst (the number of transferred embryos is 1)
Body mass index (BMI) ≤ 28 kg/m2, ≥ 18.5 kg/m2
The total number of transfer cycles was < 3
Volunteer to participate in the study and sign the informed consent

Exclusion Criteria

Patients with chromosomal abnormalities
Contraindications to hormone replacement therapy
Patients with uterine myoma, severe adenomyosis, endometriosis, congenital uterine malformation, endometrial tuberculosis, intrauterine adhesions and other diseases that significantly affect embryo implantation
Participating in other clinical studies
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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